Phosphoinositide lipids as signaling molecules: Common themes for signal transduction, cytoskeletal regulation, and membrane trafficking

Authors
Citation
Tfj. Martin, Phosphoinositide lipids as signaling molecules: Common themes for signal transduction, cytoskeletal regulation, and membrane trafficking, ANN R C DEV, 14, 1998, pp. 231-264
Citations number
198
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
ISSN journal
1081-0706 → ACNP
Volume
14
Year of publication
1998
Pages
231 - 264
Database
ISI
SICI code
1081-0706(1998)14:<231:PLASMC>2.0.ZU;2-J
Abstract
Signaling roles for phosphoinositides that involve their regulated hydrolys is to generate second messengers have been well characterized. Recent work has revealed additional signaling roles for phosphoinositides that do not i nvolve their hydrolysis. PtdIns 3-P, PtdIns 3,4,5-P-3, and PtdIns 4,5-P-2 f unction as site-specific signals on membranes that recruit and/or activate proteins for the assembly of spatially localized functional complexes. A la rge number of phosphoinositide-binding proteins have been identified as the potential effecters for phosphoinositide signals. Common themes of localiz ed signal generation and the spatially localized recruitment of effector pr oteins appear to underlie mechanisms employed in signal transduction, cytos keletal, and membrane trafficking events.