Transcriptional control of muscle development by myocyte enhancer factor-2(MEF2) proteins

Citation
Bl. Black et En. Olson, Transcriptional control of muscle development by myocyte enhancer factor-2(MEF2) proteins, ANN R C DEV, 14, 1998, pp. 167-196
Citations number
143
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
ISSN journal
1081-0706 → ACNP
Volume
14
Year of publication
1998
Pages
167 - 196
Database
ISI
SICI code
1081-0706(1998)14:<167:TCOMDB>2.0.ZU;2-7
Abstract
Metazoans contain multiple types of muscle cells that share several common properties, including contractility, excitability, and expression of overla pping sets of muscle structural genes that mediate these functions. Recent biochemical and genetic studies have demonstrated that members of the myocy te enhancer factor-2 (MEF2) family of MADS (MCM1, agamous, deficiens, serum response factor)box transcription factors play multiple roles in muscle ce lls to control myogenesis and morphogenesis. Like other MADS-box proteins, MEF2 proteins act combinatorially through protein-protein interactions with other transcription factors to control specific sets of target genes. Gene tic studies in Drosophila have also begun to reveal the upstream elements o f myogenic regulatory hierarchies that control MEF2 expression during devel opment of skeletal, cardiac, and visceral muscle lineages. Paradoxically, M EF2 factors also regulate cell proliferation by functioning as endpoints fo r a variety of growth factor-regulated intracellular signaling pathways tha t are antagonistic to muscle differentiation. We discuss the diverse functi ons of this family of transcription factors, the ways in which they are reg ulated, and their mechanisms of action.