Schistosomal granuloma modulation. II. Specific immunogenic carbohydrates can modulate schistosome-egg-antigen-induced hepatic granuloma formation

Citation
W. Jacobs et al., Schistosomal granuloma modulation. II. Specific immunogenic carbohydrates can modulate schistosome-egg-antigen-induced hepatic granuloma formation, PARASIT RES, 85(1), 1999, pp. 14-18
Citations number
33
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Microbiology
Journal title
PARASITOLOGY RESEARCH
ISSN journal
0932-0113 → ACNP
Volume
85
Issue
1
Year of publication
1999
Pages
14 - 18
Database
ISI
SICI code
0932-0113(199901)85:1<14:SGMISI>2.0.ZU;2-Z
Abstract
To further investigate the factors involved in the modulation of the schist osomal granuloma, mice were primed with immunogenic carbohydrates which wer e common to soluble egg antigen (SEA) and adult worm antigen. Mice sensitiz ed with LewisX trisaccharide or lacto-N-fucopentaose-III (LNFP-III) display ed an increased cellular response towards SEA-coupled beads implanted in th e liver by mesenteric injection, resulting in the formation of larger perip articular granulomas. When animals were sensitized with bovine serum albumi n or a structurally related carbohydrate, an accelerated response was not s een. Since LNFP-III is built up of LewisX molecules, and LewisX carbohydrat es are common to SEA and worm antigens such as the gut-secreted antigens CC A and CAA (two antigens that could prime egg-antigen-induced granuloma form ation), this may explain why adult. live Schistosoma mansoni worms positive ly modulate egg-antigen-induced hepatic granuloma formation in the murine h ost. These observations provide new insights into the role of carbohydrates in parasite-host immunity and may yield important implications for choosin g worm-derived antigens for the development of anti-schistosome vaccines.