Ovarian steroids and stress produce changes in peripheral benzodiazepine receptor density

Citation
D. Bitran et al., Ovarian steroids and stress produce changes in peripheral benzodiazepine receptor density, EUR J PHARM, 361(2-3), 1998, pp. 235-242
Citations number
53
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Toxicology
Journal title
EUROPEAN JOURNAL OF PHARMACOLOGY
ISSN journal
0014-2999 → ACNP
Volume
361
Issue
2-3
Year of publication
1998
Pages
235 - 242
Database
ISI
SICI code
0014-2999(19981120)361:2-3<235:OSASPC>2.0.ZU;2-5
Abstract
Although past research has described changes in the density of the peripher al benzodiazepine receptor in brain and in peripheral organs in response to stressors and steroid hormone exposure, their combined influence had yet t o be determined. This study examined the effect of swim-stress as a functio n of ovarian hormone administration on the binding of an isoquinoline carbo xamide derivative, [H-3]PK 11195, in brain and peripheral tissues. In olfac tory bulb and adrenal gland, stress increased peripheral benzodiazepine rec eptor density in ovariectomized rats with and without estradiol and progest erone replacement injection, even when compared with unstressed animals tre ated with hormones, when estradiol + progesterone decreased peripheral benz odiazepine receptor number in olfactory bulb, but estradiol and estradiol progesterone increased it in adrenal gland. In frontal cortex, stress decr eased peripheral benzodiazepine receptor number, an effect that was reverse d by estradiol. In hippocampus estradiol decreased peripheral benzodiazepin e receptor density in unstressed animals and estradiol + progesterone decre ased peripheral benzodiazepine receptor number in unstressed and stressed a nimals. In cerebellum stress, estradiol and estradiol + progesterone alone decreased peripheral benzodiazepine receptor density. In uterus of unstress ed controls, estradiol + progesterone increased peripheral benzodiazepine r eceptor density, and stress produced a further increase in steroid-treated females. Stress did not affect peripheral benzodiazepine receptor density i n kidney, except in animals that received estradiol + progesterone injectio ns, where swim-stress produced a significant decrease in peripheral benzodi azepine receptor density. Thus, steroid hormones regulate peripheral benzod iazepine receptor density in endocrine organs and brain, and the hormonal s tate of the organism modifies the peripheral benzodiazepine receptor respon se to stress in a tissue- and brain region-specific manner, suggesting that the peripheral benzodiazepine receptor may play a pivotal role in an integ rated response to stress. (C) 1998 Elsevier Science B.V. All rights reserve d.