ANTI-HCV ANTIBODIES IN PATIENTS WITH CHRONIC LIVER-DISEASE AND DIFFERENT AMOUNTS OF ALCOHOL INTAKE - A MULTIVARIATE-ANALYSIS

Citation
M. Tabone et al., ANTI-HCV ANTIBODIES IN PATIENTS WITH CHRONIC LIVER-DISEASE AND DIFFERENT AMOUNTS OF ALCOHOL INTAKE - A MULTIVARIATE-ANALYSIS, European journal of gastroenterology & hepatology, 5(9), 1993, pp. 749-754
Citations number
NO
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenterology & Hepatology
ISSN journal
0954-691X
Volume
5
Issue
9
Year of publication
1993
Pages
749 - 754
Database
ISI
SICI code
0954-691X(1993)5:9<749:AAIPWC>2.0.ZU;2-S
Abstract
Objective: To investigate the association between the mean daily alcoh ol intake and positivity for serum anti-hepatitis C virus antibodies i n patients with chronic liver disease of varying severity. To test the hypothesis that alcohol intake and hepatitis C virus infection have a n independent role in determining chronic liver disease. Design: Retro spective study using a multivariate analysis model. Methods: In 212 co nsecutive patients with chronic liver disease, serum anti-hepatitis C virus antibodies were detected using a second-generation test and reco mbinant immunoblotting assay. The lifetime mean daily alcohol intake w as measured by a standardized questionnaire. Patients were subsequentl y divided according to the histological presence or absence of liver c irrhosis and stratified into progressive categories of alcohol intake. The dose-effect relationship between anti-hepatitis C virus status an d mean daily alcohol intake was assessed by a model of unconditional l ogistic regression, where age, gender, degree of severity of liver dis ease and chronic hepatitis B virus infection were considered as covari ates. Results: There was a strong negative association between the mea n daily alcohol intake and the presence of anti-hepatitis C virus anti bodies, with odds ratio decreasing down to 0.01 for the category of hi ghest alcohol intake; no association was found for the other variables considered. Conclusion: Our data support the hypothesis that alcohol intake and infection with hepatitis viruses are independent determinan ts of chronic liver disease.