NEUROPSYCHOLOGICAL IMPAIRMENT IN 42 ADOLESCENTS WITH SEX-CHROMOSOME ABNORMALITIES

Citation
Bg. Bender et al., NEUROPSYCHOLOGICAL IMPAIRMENT IN 42 ADOLESCENTS WITH SEX-CHROMOSOME ABNORMALITIES, American journal of medical genetics, 48(3), 1993, pp. 169-173
Citations number
23
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Genetics & Heredity
ISSN journal
0148-7299
Volume
48
Issue
3
Year of publication
1993
Pages
169 - 173
Database
ISI
SICI code
0148-7299(1993)48:3<169:NII4AW>2.0.ZU;2-Z
Abstract
Sixty-seven adolescents participated in this protocol, including 42 wi th sex chromosome abnormalities and 25 controls. Results from a batter y of neuropsychological tests indicated karyotype specific patterns of neuropsychological impairment: (1) 47,XXY boys had unimpaired intelli gence but reduced abilities in verbal fluency and reading; (2) 47,XXX girls experienced reduced general intelligence accompanied by impaired scores on individual tests of attention, concept formation, spatial t hinking, verbal fluency, and academic skills, while retention of memor ized information was a relative strength; (3) among the 45,X girls ave rage intelligence level was also reduced along with scores on tests of attention, concept formation, verbal fluency, spatial thinking, and a cademic skills, and an atypical pattern of hand dominance was identifi ed; (4) test scores in the group of mosaic females did not differ from those of controls. Test scores and patterns of personal adaptation we re quite variable in all groups; while eight non-mosaic propositi requ ired intensive special education assistance in their public schooling, eight others have attended college. (C) 1993 Wiley-Liss, Inc.