ASYMMETRIC-SYNTHESIS OF ALPHA-KETO BETA-LACTAMS VIA [2- A CONCISE APPROACH TO OPTICALLY-ACTIVE ALPHA-HYDROXY BETA-LACTAMS AND BETA-ALKYL(ARYL)ISOSERINES(2] CYCLOADDITION REACTION )
C. Palomo et al., ASYMMETRIC-SYNTHESIS OF ALPHA-KETO BETA-LACTAMS VIA [2- A CONCISE APPROACH TO OPTICALLY-ACTIVE ALPHA-HYDROXY BETA-LACTAMS AND BETA-ALKYL(ARYL)ISOSERINES(2] CYCLOADDITION REACTION ), Tetrahedron letters, 34(39), 1993, pp. 6325-6328
The cycloaddition reaction of the Evans-Sjogren ketenes to imines, fol
lowed by alpha-hydroxylation of the resulting cycloadducts provides an
efficient general asymmetric synthesis of alpha-keto beta-lactams and
derivatives.