Ds. Prestridge et C. Burks, THE DENSITY OF TRANSCRIPTIONAL ELEMENTS IN PROMOTER AND NON-PROMOTER SEQUENCES, Human molecular genetics, 2(9), 1993, pp. 1449-1453
Using data currently available from transcriptional element (TE) datab
ases, we have analyzed the density of these elements in both promoter
and non-promoter sequences obtained from the GenBank sequence database
. The density of putative TEs in non-promoter sequences was about 16%
higher than that seen in pseudo-random DNA sequences. Promoter TE dens
ity from the transcription startsite to 100 basepairs upstream was fou
nd to be about 42% higher than in non-promoter sequences. However, the
extensive overlap of putative TE densities between promoters and non-
promoters confounds an attempt to use TE density as a simple discrimin
ator.