THE DENSITY OF TRANSCRIPTIONAL ELEMENTS IN PROMOTER AND NON-PROMOTER SEQUENCES

Citation
Ds. Prestridge et C. Burks, THE DENSITY OF TRANSCRIPTIONAL ELEMENTS IN PROMOTER AND NON-PROMOTER SEQUENCES, Human molecular genetics, 2(9), 1993, pp. 1449-1453
Citations number
30
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Genetics & Heredity",Biology
Journal title
ISSN journal
0964-6906
Volume
2
Issue
9
Year of publication
1993
Pages
1449 - 1453
Database
ISI
SICI code
0964-6906(1993)2:9<1449:TDOTEI>2.0.ZU;2-#
Abstract
Using data currently available from transcriptional element (TE) datab ases, we have analyzed the density of these elements in both promoter and non-promoter sequences obtained from the GenBank sequence database . The density of putative TEs in non-promoter sequences was about 16% higher than that seen in pseudo-random DNA sequences. Promoter TE dens ity from the transcription startsite to 100 basepairs upstream was fou nd to be about 42% higher than in non-promoter sequences. However, the extensive overlap of putative TE densities between promoters and non- promoters confounds an attempt to use TE density as a simple discrimin ator.