ANTINEOPLASTIC AGENTS .252. ISOLATION AND STRUCTURE OF HALISTATIN-2 FROM THE COMOROS MARINE SPONGE AXINELLA-CARTERI

Citation
Gr. Pettit et al., ANTINEOPLASTIC AGENTS .252. ISOLATION AND STRUCTURE OF HALISTATIN-2 FROM THE COMOROS MARINE SPONGE AXINELLA-CARTERI, Gazzetta chimica italiana, 123(7), 1993, pp. 371-377
Citations number
30
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry
Journal title
ISSN journal
0016-5603
Volume
123
Issue
7
Year of publication
1993
Pages
371 - 377
Database
ISI
SICI code
0016-5603(1993)123:7<371:AA.IAS>2.0.ZU;2-E
Abstract
An intensive long-term investigation of marine organisms as sources of new anticancer drugs has led to the isolation and structural elucidat ion (primarily by high-field NMR and mass spectrometry) of halistatin 2, 7b, a new polyether macrolide of the halipyran-type, from the Weste rn Indian Ocean sponge Axinella cf. carteri (Dendy). Halistatin 2 (1.4 x 10(-6)% yield) was accompanied by the closely related, and also str ongly antineoplastic, halistatin 1 (6b, 1.3 x 10(-6)% yield), halichon drin B (6a, 6.1 x 10(-6)% yield) and homohalichondrin B (7a, 4.3 x 10( -6)% yield). Halistatin 2, like halichondrin B and homohalichondrin B, caused the accumulation of cells arrested in mitosis, inhibited tubul in polymerization, and inhibited the binding of radiolabelled vinblast ine and GTP to tubulin.