PREMEDICATION WITH SUBLINGUAL TRIAZOLAM COMPARED WITH ORAL DIAZEPAM

Citation
Vk. Kontinen et al., PREMEDICATION WITH SUBLINGUAL TRIAZOLAM COMPARED WITH ORAL DIAZEPAM, Canadian journal of anaesthesia, 40(9), 1993, pp. 829-834
Citations number
16
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Anesthesiology
ISSN journal
0832-610X
Volume
40
Issue
9
Year of publication
1993
Pages
829 - 834
Database
ISI
SICI code
0832-610X(1993)40:9<829:PWSTCW>2.0.ZU;2-R
Abstract
The clinical effects of a new administration form of triazolam, 0.2 mg sublingual (sl) tablet, were compared with those of a 10 mg tablet of diazepam in a double-blind study, in 100 ASA I-II patients scheduled for opthalmic surgery under local anaesthesia. The sedative and anxiol ytic effects of the study drugs were followed at 15 min intervals by p lotting the patient's assessments on a visual analogue scale and by a trained observer. The onset of sedative and anxiolytic effect was simi lar At 75 min after premedication and after the operation triazolam 0. 2 mg caused deeper sedation than diazepam 10 mg according to the obser ver (P < 0.001, P < 0.01) and according to the patient (P < 0.01, P < 0.05). Ten patients (20%) in the triazolam group and one in the diazep am group were assessed to be too sedated during the operation. All the se patients were 61-70 yr old The study drugs resulted in equal reduct ion of anxiety during the preoperative period Both premedicants provid ed good patient comfort but caused total amnesia only to one patient i n each group. Neither caused any severe cardio-respiratory or other si de effects. It is concluded that 0.2 mg triazolam sl produces deeper s edation than 10 mg oral diazepam. For elderly patients this dose is ex cessive for intraocular surgery.