MORPHINE DOES NOT AFFECT THE AWAKENING CONCENTRATION OF SEVOFLURANE

Citation
T. Katoh et al., MORPHINE DOES NOT AFFECT THE AWAKENING CONCENTRATION OF SEVOFLURANE, Canadian journal of anaesthesia, 40(9), 1993, pp. 825-828
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Anesthesiology
ISSN journal
0832-610X
Volume
40
Issue
9
Year of publication
1993
Pages
825 - 828
Database
ISI
SICI code
0832-610X(1993)40:9<825:MDNATA>2.0.ZU;2-H
Abstract
This study was designed to determine whether morphine 0.1 mg, kg-1 iv given intraoperatively altered the end-tidal concentration of sevoflur ane which is associated with eye opening to verbal command. We studied 24 healthy ASA physical status I patients to determine whether morphi ne, or placebo administered about 60 min before the end of surgery aff ected recovery from sevoflurane/oxygen anaesthesia. During anaesthesia no other anaesthetics or drugs were given. After surgery, end-tidal s evoflurane concentration was reduced gradually at the rate of less tha n 0.01% . min-1. The end-tidal concentration at the time patients coul d respond to verbal command was recorded as MACawake. The MACawake was 0.58 +/- 0.12% (mean +/-SD)for the control group to whom placebo had been administered and 0.57 +/- 0.11% for morphine group to whom morphi ne had been administered In both groups, the MACawake decreased with a ge, and the ratio to age-adjusted sevoflurane MAC was 0.31 +/- 0.04 (m ean +/- SD) for the control group and 0.30 +/- 0.04 for the morphine g roup. The ratio had no correlation with age It is concluded that the a wakening concentration of sevoflurane during recovery from anaesthesia is not affected by analgesic doses of morphine 0.1 mg . kg-1 iv admin istered intraoperatively.