EFFECT OF AGE ON THE ABILITY OF RAT-LIVER TISSUES TO TRANSFORM CHEMICAL PROMUTAGENS TO MUTAGENS

Citation
A. Hilali et al., EFFECT OF AGE ON THE ABILITY OF RAT-LIVER TISSUES TO TRANSFORM CHEMICAL PROMUTAGENS TO MUTAGENS, Gerontology, 39(3), 1993, pp. 125-127
Citations number
12
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Geiatric & Gerontology
Journal title
ISSN journal
0304-324X
Volume
39
Issue
3
Year of publication
1993
Pages
125 - 127
Database
ISI
SICI code
0304-324X(1993)39:3<125:EOAOTA>2.0.ZU;2-F
Abstract
Age-related changes in drug metabolism of the liver from male Lou rats were determined by measuring changes in the production of mutagens. A ctivation of aflatoxin B1 (AFB1), 2-aminoanthracene (2AA) and benzo[a] pyrene (B[a]P) to mutagenic derivatives was assayed using the Ames sal monella test system. The promutagens were incubated with tissue fracti ons isolated from rats ranging in age from 3 weeks to 18 months. Hepat ic activation of AFB1 and 2AA changes with age and is maximal from 4 t o 10 months. In contrast, no significant modification with age was obs erved for the activation of B[a]P. It is concluded that the compositio n of different cytochrome P-450 fractions is modified with age thereby altering the specific ability to convert different promutagens to mut agens.