FREE-RADICALS AND MUSCLE DAMAGE

Citation
Mj. Jackson et S. Ofarrell, FREE-RADICALS AND MUSCLE DAMAGE, British Medical Bulletin, 49(3), 1993, pp. 630-641
Citations number
75
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medicine, General & Internal
Journal title
ISSN journal
0007-1420
Volume
49
Issue
3
Year of publication
1993
Pages
630 - 641
Database
ISI
SICI code
0007-1420(1993)49:3<630:FAMD>2.0.ZU;2-P
Abstract
Muscle tissue is unique in its requirement and ability to undertake ve ry rapid and co-ordinated changes in energy supply and oxygen flux dur ing contraction. Several studies have suggested that this renders the tissue particularly prone to oxygen radical-mediated damage. Free radi cals have been postulated to play a role in muscle damage induced by d ifferent forms of exercise and in various pathological disorders, such as the muscular dystrophies, malignant hyperthermia and alcoholic myo pathy. However, conclusive evidence for a fundamental role for free ra dicals and protective effect of antioxidants remains elusive in all th ese situations and much further work on the relevant pathogenetic mech anisms is still required.