LOWERING EFFECT OF DIETARY MILK-WHEY PROTEIN V CASEIN ON PLASMA AND LIVER CHOLESTEROL CONCENTRATIONS IN RATS

Citation
Xz. Zhang et Ac. Beynen, LOWERING EFFECT OF DIETARY MILK-WHEY PROTEIN V CASEIN ON PLASMA AND LIVER CHOLESTEROL CONCENTRATIONS IN RATS, British Journal of Nutrition, 70(1), 1993, pp. 139-146
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Nutrition & Dietetics
ISSN journal
0007-1145
Volume
70
Issue
1
Year of publication
1993
Pages
139 - 146
Database
ISI
SICI code
0007-1145(1993)70:1<139:LEODMP>2.0.ZU;2-9
Abstract
The effect of dietary whey protein v. casein on plasma and liver chole sterol concentrations was investigated in female, weanling rats. Balan ced, purified diets containing either whey protein or casein, or the a mino acid mixtures simulating these proteins, were used. The high-chol esterol diets (10 g cholesterol/kg feed) had either 150 or 300 g prote in or amino acids/kg feed. The diets were fed for 3 weeks. At the low dietary protein level, whey protein v. casein did not affect plasma to tal cholesterol, but lowered the concentration of liver cholesterol. A t the high dietary protein level, whey protein significantly lowered p lasma and liver cholesterol and also plasma triacylglycerols. The hypo cholesterolaemic effect of whey protein was associated with a decrease in very-low-density-lipoprotein cholesterol. At the high dietary prot ein concentration, whey protein reduced the faecal excretion of bile a cids when compared with casein. The effects of intact whey protein v. casein were not reproduced by the amino acid mixtures simulating these proteins. It is suggested tentatively that the cholesterol-lowering e ffect of whey protein in rats is caused by inhibition of hepatic chole sterol synthesis.