AMOUNT AND DURATION OF ALCOHOL INTAKE AS RISK-FACTORS OF SYMPTOMATIC LIVER-CIRRHOSIS - A CASE-CONTROL STUDY

Citation
G. Corrao et al., AMOUNT AND DURATION OF ALCOHOL INTAKE AS RISK-FACTORS OF SYMPTOMATIC LIVER-CIRRHOSIS - A CASE-CONTROL STUDY, Journal of clinical epidemiology, 46(7), 1993, pp. 601-607
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Public, Environmental & Occupation Heath","Medicine, General & Internal
ISSN journal
0895-4356
Volume
46
Issue
7
Year of publication
1993
Pages
601 - 607
Database
ISI
SICI code
0895-4356(1993)46:7<601:AADOAI>2.0.ZU;2-A
Abstract
We carried out a hospital based case-control study involving 320 patie nts with symptomatic liver cirrhosis (LC) and 320 pair-matched control individuals, in order to estimate the dose-response relationship betw een both the daily amount and the duration of alcohol intake and the r isk of LC. Lifetime alcohol consumption was measured by a standardized and reproducible questionnaire, and expressed as lifetime daily alcoh ol intake (LDAI) and duration of alcohol consumption (DAC). The odds r atio (OR) for LC was estimated by the conditional logistic regression. It increased from 1.0 for lifetime abstainers to 4.2 for LDAI of 225 g or more. Comparing durations of alcohol consumption of less-than-or- equal-to 10 and greater-than-or-equal-to 30 years in the model, the OR s consistently decreased for all the LDAI categories: from 4.1 to 0.6 in the 25-50 g category; from 15.1 to 0.9 in the 75-100 g category; fr om 67.2 to 1.5 in the 125 g or more category. Our results suggest that the dose-dependent relationship between alcohol and LC may be mediate d by the degree of individual susceptibility to the detrimental effect of alcohol to the liver.