WORTMANNIN ENHANCES CPP32-LIKE ACTIVITY DURING NEURONAL DIFFERENTIATION OF P19 EMBRYONAL CARCINOMA-CELLS INDUCED BY RETINOIC ACID

Citation
T. Mukasa et al., WORTMANNIN ENHANCES CPP32-LIKE ACTIVITY DURING NEURONAL DIFFERENTIATION OF P19 EMBRYONAL CARCINOMA-CELLS INDUCED BY RETINOIC ACID, Biochemical and biophysical research communications, 232(1), 1997, pp. 192-197
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biology,Biophysics
ISSN journal
0006-291X
Volume
232
Issue
1
Year of publication
1997
Pages
192 - 197
Database
ISI
SICI code
0006-291X(1997)232:1<192:WECADN>2.0.ZU;2-E
Abstract
P19EC cells undergoes apoptosis during neuronal differentiation induce d by retinoic acid. Two CPP32-like proteases, CPP32 and Mch-3, are exp ressed in untreated and retinoic acid-treated P19 EC cells. CPP32-like activity is remarkably increased in apoptosis during neuronal differe ntiation of P19 EC cells. Inhibition of CPP32-like proteases prevents apoptosis, suggesting that activation of CPP32-like proteases play cen tral roles in the apoptosis during neuronal differentiation of P19 EC cells. Wortmannin, PI-3K inhibitor, enhances the CPP32-like activity o f the retinoic acid-treated P19 EC cells. PI-3K may be involved in the apoptosis during neuronal differentiation as negative regulator. (C) 1997 Academic Press.