CLINICAL PRESENTATION AND OUTCOME OF LISTERIOSIS IN PATIENTS WITH ANDWITHOUT IMMUNOSUPPRESSIVE THERAPY

Citation
K. Skogberg et al., CLINICAL PRESENTATION AND OUTCOME OF LISTERIOSIS IN PATIENTS WITH ANDWITHOUT IMMUNOSUPPRESSIVE THERAPY, Clinical infectious diseases, 14(4), 1992, pp. 815-821
Citations number
33
Language
INGLESE
art.tipo
Article
ISSN journal
1058-4838
Volume
14
Issue
4
Year of publication
1992
Pages
815 - 821
Database
ISI
SICI code
1058-4838(1992)14:4<815:CPAOOL>2.0.ZU;2-5
Abstract
Seventy-four cases of systemic listeriosis occurring from 1971 to 1989 in the greater Helsinki area in Finland are reviewed with a special i nterest in the effect of preceding immunosuppressive therapy on the cl inical presentation. Of these patients, 66% had an underlying disease, most commonly malignancy, diabetes mellitus, or renal transplantation , and 43% had received immunosuppressive therapy within 1 week before onset of listeriosis. Bacteremia and central nervous system infections (both in 43% of cases) were the most common clinical entities. The pe rcentage of patients with meningitis was not greater among immunosuppr essed patients (13/32, 41%) than among patients with underlying diseas es not treated with immunosuppressive agents (9/16, 56%) or among prev iously healthy nonpregnant hosts (7/11, 64%). Immunosuppressed patient s did not die more frequently than did those with underlying diseases not treated with immunosuppressive therapy (case fatality rate, 29% vs . 38%, respectively). However, all previously healthy non-neonatal pat ients survived, whereas 32% (15/47) of those with any kind of underlyi ng disease succumbed.