EFFICACY AND SAFETY OF SHORT INTRAVENOUS AMIODARONE IN SUPRAVENTRICULAR TACHYARRHYTHMIAS

Citation
G. Viettiramus et al., EFFICACY AND SAFETY OF SHORT INTRAVENOUS AMIODARONE IN SUPRAVENTRICULAR TACHYARRHYTHMIAS, International journal of cardiology, 35(1), 1992, pp. 77-85
Citations number
30
Language
INGLESE
art.tipo
Article
ISSN journal
0167-5273
Volume
35
Issue
1
Year of publication
1992
Pages
77 - 85
Database
ISI
SICI code
0167-5273(1992)35:1<77:EASOSI>2.0.ZU;2-R
Abstract
The safety and efficacy of short intravenous therapy with amiodarone w ere evaluated in 44 patients (24 males, 20 females), aged 21-84 years, with supraventricular tachyarrhythmias newly arisen in less than 24 h ours. The study group consisted of 15 patients with paroxysmal suprave ntricular tachycardia, 8 patients with atrial flutter and 21 patients with atrial fibrillation. They were treated with a single infusion of amiodarone up to 2 hours after the restoration of a stable sinus rhyth m, or up to a maximum dose of 2400 mg in 24 hours. Our study shows tha t 88.6% of all supraventricular tachyarrhythmias reverts to sinus rhyt hm in less than 24 hours: 100% of paroxysmal supraventricular tachycar dia, 75% of atrial flutter, and 85.7% of atrial fibrillation. Intraven ously administered amiodarone proves to take effect rapidly (0.5 to 22 hours). The plasma amiodarone concentrations at sinus rhythm restorat ion showed a wide range (405-3800 ng/ml). Piecewise analysis suggested that the probability of sinus rhythm was 14.4-fold greater in paroxys mal supraventricular tachycardia. No linear statistical relationship w as detectable between the log-dose-body mass index and log-QTc. Total amiodarone dose and left atrial volume are inversely correlated with a statistically significant difference. The toxicity in our short intra venous course with amiodarone was not relevant. We conclude that short high-dose intravenous amiodarone shows efficacy and safety in all new ly occurring supraventricular tachyarrhythmias.