DIRECT AND INDIRECT STIMULATIONS OF CYCLIC-AMP FORMATION IN HUMAN BRAIN

Citation
Da. Kendall et al., DIRECT AND INDIRECT STIMULATIONS OF CYCLIC-AMP FORMATION IN HUMAN BRAIN, British Journal of Pharmacology, 105(4), 1992, pp. 899-902
Citations number
17
Language
INGLESE
art.tipo
Article
ISSN journal
0007-1188
Volume
105
Issue
4
Year of publication
1992
Pages
899 - 902
Database
ISI
SICI code
0007-1188(1992)105:4<899:DAISOC>2.0.ZU;2-K
Abstract
1 Adenosine 3':5'-cyclic monophosphate (cyclic AMP) formation, by use of an [H-3]-adenine prelabelling assay, was measured in fragments of h uman cerebral cortex, taken in the course of various neurosurgical pro cedures. 2 Large accumulations of [H-3]-cyclic AMP due to isoprenaline , noradrenaline and adenosine and small effects due to forskolin were observed. Histamine, 5-hydroxytryptamine (5-HT) and the excitatory ami no acids glutamate and quisqualate were ineffective. 3 The response to noradrenaline consisted of two components; a direct beta-adrenoceptor response and an enhancement mediated by an alpha-adrenoceptor which a ppears to be similar to that in rat cerebral cortex. 4 The response to isoprenaline was also potentiated by histamine H-1 receptor stimulati on but the direct effect of 2-chloroadenosine was not altered by hista mine, 5-HT or quisqualate. 5 It is concluded that some, but not all, o f the indirect modulations of cyclic AMP formation previously observed in experimental animal brain exist in human cerebral cortex.