IDENTIFICATION OF INHIBITORS OF NITRIC-OXIDE SYNTHASE THAT DO NOT INTERACT WITH THE ENDOTHELIAL-CELL L-ARGININE TRANSPORTER

Citation
Rg. Bogle et al., IDENTIFICATION OF INHIBITORS OF NITRIC-OXIDE SYNTHASE THAT DO NOT INTERACT WITH THE ENDOTHELIAL-CELL L-ARGININE TRANSPORTER, British Journal of Pharmacology, 105(4), 1992, pp. 768-770
Citations number
11
Language
INGLESE
art.tipo
Article
ISSN journal
0007-1188
Volume
105
Issue
4
Year of publication
1992
Pages
768 - 770
Database
ISI
SICI code
0007-1188(1992)105:4<768:IOIONS>2.0.ZU;2-N
Abstract
The effects of inhibitors of nitric oxide (NO) synthase and other cati onic amino acids on unidirectional L-arginine transport were studied i n porcine aortic endothelial cells cultured in microwell plates or per fused in microcarrier columns. L-Homoarginine, L-lysine and L-ornithin e inhibited transport of L-arginine. The NO synthase inhibitors N(G)-m onomethyl-L-arginine and N(G)-iminoethyl-L-ornithine also reduced L-ar ginine uptake, whereas N(G)-nitro-L-arginine and its methyl-ester had no inhibitory effect. The ability to modulate selectively endothelial cell L-arginine transport or NO synthase activity will allow further c haracterization of the arginine transporter and its role in regulating NO biosynthesis.