Y. Zhang et Ww. Lautt, ARTERIAL AND VENOUS PLASMA-CONCENTRATIONS OF ADENOSINE DURING HEMORRHAGE, British Journal of Pharmacology, 105(4), 1992, pp. 765-767
A haemorrhage model was used to impose severe metabolic stress in anae
sthetized cats by removing blood (15.3 ml min-1) to attain an arterial
pressure of ca. 50 mmHg for a 2 h period. Adenosine levels in central
venous blood rose by 5 min, reached a peak of about 3.5 times control
levels by 15 min and then returned to the basal level (1-mu-M) by 60
min. However, the adenosine concentration in arterial blood remained u
nchanged for the entire 2 h period of hypotension. These data demonstr
ate that haemorrhage results in rapid adenosine release, but the relea
sed adenosine is not able to serve a role as a systemic circulating va
sodilator even in this severe model.