ARTERIAL AND VENOUS PLASMA-CONCENTRATIONS OF ADENOSINE DURING HEMORRHAGE

Authors
Citation
Y. Zhang et Ww. Lautt, ARTERIAL AND VENOUS PLASMA-CONCENTRATIONS OF ADENOSINE DURING HEMORRHAGE, British Journal of Pharmacology, 105(4), 1992, pp. 765-767
Citations number
8
Language
INGLESE
art.tipo
Article
ISSN journal
0007-1188
Volume
105
Issue
4
Year of publication
1992
Pages
765 - 767
Database
ISI
SICI code
0007-1188(1992)105:4<765:AAVPOA>2.0.ZU;2-2
Abstract
A haemorrhage model was used to impose severe metabolic stress in anae sthetized cats by removing blood (15.3 ml min-1) to attain an arterial pressure of ca. 50 mmHg for a 2 h period. Adenosine levels in central venous blood rose by 5 min, reached a peak of about 3.5 times control levels by 15 min and then returned to the basal level (1-mu-M) by 60 min. However, the adenosine concentration in arterial blood remained u nchanged for the entire 2 h period of hypotension. These data demonstr ate that haemorrhage results in rapid adenosine release, but the relea sed adenosine is not able to serve a role as a systemic circulating va sodilator even in this severe model.