AN IMMUNOHISTOCHEMICAL STUDY OF PERIANAL PAGETS-DISEASE - POSSIBLE ORIGINS AND CLINICAL IMPLICATIONS

MILLER LR MCCUNNIFF AJ RANDALL ME

Lr. Miller et al., AN IMMUNOHISTOCHEMICAL STUDY OF PERIANAL PAGETS-DISEASE - POSSIBLE ORIGINS AND CLINICAL IMPLICATIONS, Cancer, 69(8), 1992, pp. 2166-2171

35

INGLESE

Article

Cancer → ACNP

0008-543X

69

8

1992

2166 - 2171

ISI

0008-543X(1992)69:8<2166:AISOPP>2.0.ZU;2-O

The histogenesis of perianal Paget's disease is controversial. A clini cal and pathologic study was done of a patient with a history of adeno carcinoma of the rectum for whom a subsequent diagnosis of perianal Pa get's disease was the sole manifestation of recurrent rectal cancer. I mmunohistochemical techniques were used to compare and contrast the or iginal rectal adenocarcinoma with the subsequent perianal skin recurre nce confined to the epidermis. Both the rectal adenocarcinoma and the Paget's cells were positive for cytokeratin, epithelial membrane antig en, B72.3, and carcinoembryonic antigen and negative for gross cystic disease fluid protein-15, Leu-M1, CA 125, and S-100 protein. These fin dings, their relevance to the histogenesis of perianal Paget's disease , and the possible clinical implications are discussed.