EXTRANEURAL METASTASES OF INFRATENTORIAL GLIOBLASTOMA-MULTIFORME TO THE PERITONEAL-CAVITY

Citation
Hb. Newton et al., EXTRANEURAL METASTASES OF INFRATENTORIAL GLIOBLASTOMA-MULTIFORME TO THE PERITONEAL-CAVITY, Cancer, 69(8), 1992, pp. 2149-2153
Citations number
22
Language
INGLESE
art.tipo
Article
Journal title
CancerACNP
ISSN journal
0008-543X
Volume
69
Issue
8
Year of publication
1992
Pages
2149 - 2153
Database
ISI
SICI code
0008-543X(1992)69:8<2149:EMOIGT>2.0.ZU;2-U
Abstract
This report describes two autopsy-proven cases of a rare complication of infratentorial glioblastoma multiforme (GBM): metastatic seeding of the peritoneal cavity through ventriculoperitoneal (VP) shunts. Patie nt 1 was a 13-year-old boy with a pontine GBM, and Patient 2 was a 9-y ear-old girl with a thoracolumbar spinal cord GBM. Autopsy of both pat ients demonstrated leptomeningeal gliomatosis encasing the spinal cord and basal structures of the brain, in addition to peritoneal and omen tal metastases. The pattern of abdominal metastasis seen in these pati ents is typical of tumors that directly seed the peritoneal cavity and implicates the VP shunt as the vehicle of extraneural spread. Althoug h a rare occurrence, extraneural metastases should be sought in patien ts with glioma with VP shunts who demonstrate increased abdominal girt h, unexplained weight gain, or persistent abdominal pain.