OVARIAN MUCINOUS TUMORS FREQUENTLY EXPRESS MARKERS OF GASTRIC, INTESTINAL, AND PANCREATICOBILIARY EPITHELIAL-CELLS

Citation
P. Tenti et al., OVARIAN MUCINOUS TUMORS FREQUENTLY EXPRESS MARKERS OF GASTRIC, INTESTINAL, AND PANCREATICOBILIARY EPITHELIAL-CELLS, Cancer, 69(8), 1992, pp. 2131-2142
Citations number
35
Language
INGLESE
art.tipo
Article
Journal title
CancerACNP
ISSN journal
0008-543X
Volume
69
Issue
8
Year of publication
1992
Pages
2131 - 2142
Database
ISI
SICI code
0008-543X(1992)69:8<2131:OMTFEM>2.0.ZU;2-L
Abstract
In 100 mucinous tumors of the ovary (37 benign, 24 borderline, and 39 malignant), the authors determined by histochemical and immunohistoche mical techniques the frequencies and patterns of expression of a total of nine markers of gastric, intestinal, and pancreatobiliary duct epi thelial cells. M1, a mucin antigen, and cathepsin E (CaE), an aspartic proteinase, two markers of normal gastric superficial/foveolar epithe lial cells, were expressed in 95 and 92 tumors, respectively. Periodic acid-concanavalin A-reactive mucin or pepsinogen (PG) II, markers of gastric mucus neck and pyloric gland cells, were found in 79 tumors. A ll of these tumors also expressed M1 or CaE. DU-PAN-2 and the N-termin al epitope of gastrin-releasing peptide, markers of normal pancreatobi liary duct cells, were found in 70 and 49 tumors, respectively, and CA R-5 and M3SI, markers of intestinal mucin, were expressed in 51 and 30 tumors, respectively. All tumors expressed at least two of the nine m arkers studied; none expressed PG I, a marker of gastric chief cells. The mucopeptic cell marker, PG II, was significantly more common in be nign and borderline than in malignant tumors (P < 0.005), whereas CAR- 5 and M3SI, markers of intestinal mucin, were expressed significantly more often in malignant than in benign and borderline tumors (P < 0.00 1). By electron microscopic examination, many tumor cells had fine str uctural features characteristic of gastric superficial/foveolar and py loric gland cells, intestinal columnar or goblet cells, and endocervic al cells. The results indicate that gastroenteropancreatic cell differ entiation-and, in particular, gastric type differentiation-is a promin ent feature of ovarian mucinous tumors.