PROGNOSTIC FACTORS IN 227 PATIENTS WITH MALIGNANT FIBROUS HISTIOCYTOMA

Citation
Cm. Pezzi et al., PROGNOSTIC FACTORS IN 227 PATIENTS WITH MALIGNANT FIBROUS HISTIOCYTOMA, Cancer, 69(8), 1992, pp. 2098-2103
Citations number
33
Language
INGLESE
art.tipo
Article
Journal title
CancerACNP
ISSN journal
0008-543X
Volume
69
Issue
8
Year of publication
1992
Pages
2098 - 2103
Database
ISI
SICI code
0008-543X(1992)69:8<2098:PFI2PW>2.0.ZU;2-Q
Abstract
Malignant fibrous histiocytoma, the major subset of soft tissue sarcom as, was examined for prognostic factors that could influence clinical management and research. Two hundred twenty-seven patients with locali zed disease, having surgery as the principal modality, were reviewed r etrospectively to identify clinical outcomes. The mean age of the pati ents was 54 years. Extremities were the primary tumor site in 157 pati ents (62.2%). Overall survival rate was 50% including 38 patients who died of other causes. Distant metastases were most common to the lung (90%). Local recurrence alone occurred in 37 patients (16%), distant m etastases alone in 52 (23%), and distant metastases with local recurre nce in 25 (11%). The primary tumor size indicated the 5-year survival rate: tumors smaller than 5 cm had a survival rate of 82%; 5 to 10 cm, 68%; and larger than 10 cm, 51%. Intermediate-grade tumors yielded a 5-year survival rate of 80%, and the 5-year survival rate for high-gra de tumors was 60%. Survival rates for both grades were affected by siz e: tumors of high grade and smaller than 5 cm in diameter had a surviv al rate of 79%; 5 to 10 cm, 63%; and more than 10 cm, 41%. Grade and s ize emerge as significant prognostic indicators. These variables will prove helpful in treatment decisions and design of clinical studies.