CARBOHYDRATE PROFILES SHOWN BY A LECTIN AND A MONOCLONAL-ANTIBODY CORRELATE WITH METASTATIC POTENTIAL AND PROGNOSIS OF HUMAN LUNG CARCINOMAS

Citation
H. Matsumoto et al., CARBOHYDRATE PROFILES SHOWN BY A LECTIN AND A MONOCLONAL-ANTIBODY CORRELATE WITH METASTATIC POTENTIAL AND PROGNOSIS OF HUMAN LUNG CARCINOMAS, Cancer, 69(8), 1992, pp. 2084-2090
Citations number
32
Language
INGLESE
art.tipo
Article
Journal title
CancerACNP
ISSN journal
0008-543X
Volume
69
Issue
8
Year of publication
1992
Pages
2084 - 2090
Database
ISI
SICI code
0008-543X(1992)69:8<2084:CPSBAL>2.0.ZU;2-R
Abstract
The expression of two carbohydrate markers-namely, 4C9 antigen, which is an Le(x) antigen, and the Dolichos biflorus agglutinin (DBA) bindin g site, which is an N-acetylgalactosamine marker-was examined histoche mically in tumors and adjacent nontumorous tissues of 102 cases of hum an lung carcinomas. In nontumorous tissues, the DBA binding site was e xpressed more frequently than 4C9 antigen, and the DBA binding site ha d a tendency to be expressed more significantly than in tumor cells. A denocarcinomas and well-differentiated tumors had a tendency to more c ell surface staining. Patients with tumors that expressed DBA binding sites but not 4C9 antigen (4C9-, DBA+) had fewer metastasis and signif icantly better prognoses than patients with tumors of other carbohydra te profiles. Better prognosis of patients with 4C9-, DBA+ tumors was o bserved in those with blood group A antigen and those without it, and the better prognosis also was observed in patients with Stage I and II IA disease.