CARBOHYDRATE PROFILES SHOWN BY A LECTIN AND A MONOCLONAL-ANTIBODY CORRELATE WITH METASTATIC POTENTIAL AND PROGNOSIS OF HUMAN LUNG CARCINOMAS

MATSUMOTO H MURAMATSU H MURAMATSU T SHIMAZU H

H. Matsumoto et al., CARBOHYDRATE PROFILES SHOWN BY A LECTIN AND A MONOCLONAL-ANTIBODY CORRELATE WITH METASTATIC POTENTIAL AND PROGNOSIS OF HUMAN LUNG CARCINOMAS, Cancer, 69(8), 1992, pp. 2084-2090

32

INGLESE

Article

Cancer → ACNP

0008-543X

69

8

1992

2084 - 2090

ISI

0008-543X(1992)69:8<2084:CPSBAL>2.0.ZU;2-R

The expression of two carbohydrate markers-namely, 4C9 antigen, which is an Le(x) antigen, and the Dolichos biflorus agglutinin (DBA) bindin g site, which is an N-acetylgalactosamine marker-was examined histoche mically in tumors and adjacent nontumorous tissues of 102 cases of hum an lung carcinomas. In nontumorous tissues, the DBA binding site was e xpressed more frequently than 4C9 antigen, and the DBA binding site ha d a tendency to be expressed more significantly than in tumor cells. A denocarcinomas and well-differentiated tumors had a tendency to more c ell surface staining. Patients with tumors that expressed DBA binding sites but not 4C9 antigen (4C9-, DBA+) had fewer metastasis and signif icantly better prognoses than patients with tumors of other carbohydra te profiles. Better prognosis of patients with 4C9-, DBA+ tumors was o bserved in those with blood group A antigen and those without it, and the better prognosis also was observed in patients with Stage I and II IA disease.