The monoclonal antibody against human hepatocellular carcinoma, HAb23,
was conjugated with radioiodine and injected into nude mice with huma
n hepatoma xenografts. After 4 to 5 days, the nude mice were scanned b
y emission computerized topography. The results showed that the xenogr
afts were distinguished clearly. The tumor-liver and tumor-blood ratio
s were 1.94 to 3.66 and 0.56 to 1.65, respectively. Autoradiography sh
owed that the HAb23 was localized mainly on the surface membrane and t
ubulovesicular systems of the tumor cells.