RADIOIMMUNODETECTION AND AUTORADIOGRAPHIC LOCALIZATION OF MONOCLONAL-ANTIBODY AGAINST HUMAN HEPATOCELLULAR-CARCINOMA IN XENOGRAFTS

Authors
Citation
Yy. Ji et al., RADIOIMMUNODETECTION AND AUTORADIOGRAPHIC LOCALIZATION OF MONOCLONAL-ANTIBODY AGAINST HUMAN HEPATOCELLULAR-CARCINOMA IN XENOGRAFTS, Cancer, 69(8), 1992, pp. 2055-2059
Citations number
11
Language
INGLESE
art.tipo
Article
Journal title
CancerACNP
ISSN journal
0008-543X
Volume
69
Issue
8
Year of publication
1992
Pages
2055 - 2059
Database
ISI
SICI code
0008-543X(1992)69:8<2055:RAALOM>2.0.ZU;2-#
Abstract
The monoclonal antibody against human hepatocellular carcinoma, HAb23, was conjugated with radioiodine and injected into nude mice with huma n hepatoma xenografts. After 4 to 5 days, the nude mice were scanned b y emission computerized topography. The results showed that the xenogr afts were distinguished clearly. The tumor-liver and tumor-blood ratio s were 1.94 to 3.66 and 0.56 to 1.65, respectively. Autoradiography sh owed that the HAb23 was localized mainly on the surface membrane and t ubulovesicular systems of the tumor cells.