CARCINOSARCOMA OF THE SUBMANDIBULAR SALIVARY-GLAND - IMMUNOHISTOCHEMICAL FINDINGS

Citation
Ij. Bleiweiss et al., CARCINOSARCOMA OF THE SUBMANDIBULAR SALIVARY-GLAND - IMMUNOHISTOCHEMICAL FINDINGS, Cancer, 69(8), 1992, pp. 2031-2035
Citations number
17
Language
INGLESE
art.tipo
Article
Journal title
CancerACNP
ISSN journal
0008-543X
Volume
69
Issue
8
Year of publication
1992
Pages
2031 - 2035
Database
ISI
SICI code
0008-543X(1992)69:8<2031:COTSS->2.0.ZU;2-7
Abstract
Carcinosarcomas of the salivary glands are rare lesions that generally have been associated with benign mixed tumors. The authors report a c ase of a submandibular gland lesion, which occurred in a 64-year-old m an, that was composed of intermingled ductal type adenocarcinoma and o steogenic sarcoma with a large component of osteoclast-like giant cell s. The local recurrence of the tumor was entirely sarcomatous with no epithelial component observed. There was no histologic evidence of a p reexisting or coexisting pleomorphic adenoma. Immunohistochemical stud ies confirmed two separate populations of tumor cells, corresponding t o the histologic growth pattern. The authors review the literature and discuss histogenetic implications of distinction between de novo carc inosarcoma and carcinosarcoma in association with pleomorphic adenoma.