PATHOGENESIS OF ORAL SUBMUCOUS FIBROSIS - RELATIONSHIP TO RISK-FACTORS ASSOCIATED WITH ORAL-CANCER

Citation
R. Pillai et al., PATHOGENESIS OF ORAL SUBMUCOUS FIBROSIS - RELATIONSHIP TO RISK-FACTORS ASSOCIATED WITH ORAL-CANCER, Cancer, 69(8), 1992, pp. 2011-2020
Citations number
123
Language
INGLESE
art.tipo
Review
Journal title
CancerACNP
ISSN journal
0008-543X
Volume
69
Issue
8
Year of publication
1992
Pages
2011 - 2020
Database
ISI
SICI code
0008-543X(1992)69:8<2011:POOSF->2.0.ZU;2-I
Abstract
Oral submucous fibrosis (OSF) is a chronic disease of the oral mucosa characterized by inflammation and a progressive fibrosis of the lamina propria and deeper connective tissues. It is a condition predominantl y seen among people of Indian origin, and an epidemiologic survey done a decade ago showed no less than 250,000 cases in India, a figure tha t must have increased sharply. OSF is a condition with a high risk of malignant transformation; to date, no conclusive etiologic agent has b een identified, although plenty of data have been generated on various aspects of the disease. These include genetic, carcinogenic, immunolo gic, viral, nutritional, and autoimmune possibilities, all of which al so have been implicated in the development of oral cancer. This articl e reviews existing evidence on the pathogenesis of OSF and its relatio n to oral cancer and suggests a possible multifactorial model to expla in the disease process.