CYTOTOXIC EFFECT OF PLANT POLYPHENOLS AND FAT-SOLUBLE VITAMINS ON MALIGNANT HUMAN CULTURED-CELLS

Authors
RAMANATHAN R TAN CH DAS NP
Citation
R. Ramanathan et al., CYTOTOXIC EFFECT OF PLANT POLYPHENOLS AND FAT-SOLUBLE VITAMINS ON MALIGNANT HUMAN CULTURED-CELLS, Cancer letters, 62(3), 1992, pp. 217-224
Citations number
28
Language
INGLESE
art.tipo
Article
Journal title
Cancer letters → ACNP
ISSN journal
0304-3835
Volume
62
Issue
3
Year of publication
1992
Pages
217 - 224
Database
ISI
SICI code
0304-3835(1992)62:3<217:CEOPPA>2.0.ZU;2-N
Abstract
In vitro studies showed that several flavonoids, tannic acid, gallic a cid and fat-soluble vitamins inhibited HeLa and Raji lymphoma cell gro wth. The inhibition trend exhibited by these compounds was similar for both cell lines, and their growth was inhibited dose dependently. But ein, (10-mu-M), the most potent anti-proliferative agent, exerted 30% growth inhibition and was more effective on HeLa cells. Retinol (100-m u-M) inhibited cell proliferation completely. Tannic acid was twice as potent as its monomer gallic acid. From structure-activity considerat ion, the C2,3-double bond of the flavonoid molecule was important for activity. Flavonoid aglycones were more effective than their correspon ding glycosides in suppressing cell growth.