ELEVATED SERUM MANGANESE SUPEROXIDE-DISMUTASE IN ACUTE LEUKEMIAS

Authors
NISHIURA T SUZUKI K KAWAGUCHI T NAKAO H KAWAMURA N TANIGUCHI M KANAYAMA Y YONEZAWA T TANIGUCHI N
Citation
T. Nishiura et al., ELEVATED SERUM MANGANESE SUPEROXIDE-DISMUTASE IN ACUTE LEUKEMIAS, Cancer letters, 62(3), 1992, pp. 211-215
Citations number
13
Language
INGLESE
art.tipo
Article
Journal title
Cancer letters → ACNP
ISSN journal
0304-3835
Volume
62
Issue
3
Year of publication
1992
Pages
211 - 215
Database
ISI
SICI code
0304-3835(1992)62:3<211:ESMSIA>2.0.ZU;2-M
Abstract
We measured the serum levels of manganese-superoxide dismutase (Mn-SOD ) in acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL). S erum Mn-SOD level for normal subjects was 94.1 +/- 23.5 ng/ml (mean +/ - S.D.), the levels for AML and ALL patients were 159.6 +/- 77.1 ng/ml and 154.4 +/- 77.0 ng/ml, respectively. The serum Mn-SOD levels were unrelated to individual intracellular Mn-SOD levels, but correlated we ll with serum lactate dehydrogenase values. Regression of the leukemia was accompanied by decrease in the serum level of Mn-SOD. Serum Mn-SO D may thus serve as a measure of the activity of the disease.