ELECTROPHYSIOLOGIC EFFECTS OF PROPOFOL SEDATION

Citation
Jr. Sneyd et al., ELECTROPHYSIOLOGIC EFFECTS OF PROPOFOL SEDATION, Anesthesia and analgesia, 79(6), 1994, pp. 1151-1158
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Anesthesiology
Journal title
ISSN journal
0003-2999
Volume
79
Issue
6
Year of publication
1994
Pages
1151 - 1158
Database
ISI
SICI code
0003-2999(1994)79:6<1151:EEOPS>2.0.ZU;2-2
Abstract
The scalp electroencephalogram (EEG), the long latency cognitive P300 auditory evoked response (AER), and reaction times were recorded in 10 volunteers sedated with a computer-controlled infusion of propofol to target plasma concentrations of 0.3, 0.6, 0.9, and 1.2 mu g/mL. The o bserved mean +/- SE venous plasma concentrations were 0.152 +/- 0.042, 0.372 +/- 0.078, 0.679 +/- 0.104, and 1.065 +/- 0.112 mu g/mL, respec tively. Scalp EEG topographic mapping revealed that beta(1) activation was primarily frontal and central with relative sparing of the tempor al lobes. The P300 response was dramatically reduced by propofol in a concentration-dependent manner, even though the subjects were consciou s but clearly sedated. Mean ise reaction times were increased by propo fol sedation from 347 +/- 35 ms (control) to 391 +/- 48, 460 +/- 70, 5 49 +/- 64, and 622 +/- 120 ms at increasing mean venous plasma propofo l concentrations. The mean percentage +/- SE of correct responses decr eased from 98.1 +/- 2.0 (control) to 99.1 +/- 1.7, 87.4 +/- 9.2, 82.8 +/- 12.9, and 69.8 +/- 20.9 at increasing propofol concentrations. Dra matic alterations in the EEG, P300 response, and reaction times were o bserved, especially with the higher plasma concentrations which produc ed conscious sedation.