CURRENT STATUS OF PROSTATE-CANCER RESEARCH - DEVELOPMENT OF IN-VITRO MODEL SYSTEMS (REVIEW)

Authors
Citation
Ja. Chah et Js. Rhim, CURRENT STATUS OF PROSTATE-CANCER RESEARCH - DEVELOPMENT OF IN-VITRO MODEL SYSTEMS (REVIEW), International journal of oncology, 5(6), 1994, pp. 1233-1242
Citations number
110
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Oncology
ISSN journal
1019-6439
Volume
5
Issue
6
Year of publication
1994
Pages
1233 - 1242
Database
ISI
SICI code
1019-6439(1994)5:6<1233:CSOPR->2.0.ZU;2-7
Abstract
Prostate cancer is a major medical problem which is expected to affect over 200,000 US men in 1994. Despite its widespread prevalence and th e difficulties in clinical diagnosis and treatment of the disease, the contribution of environmental factors and the etiological mechanism o f prostate cancer are poorly understood. A brief update on recent prog ress in cellular and molecular research of prostate cancer is provided . Specific areas discussed include oncogenes (vas, myc, c-erbB-2 and b cl-2), tumor suppressor genes (p53, RB, DCC, putative suppressor genes ), growth factors (EGF, FGF, IGF) and human papillomavirus (HPV) infec tions. The elucidation of a multistep mechanism of prostate tumorigene sis has been slowed by a lack of tumor tissue and the limited number o f in vitro cell lines available for study. Reviewed here are the newly developed in vitro normal prostate cell systems which supply a base f or addition of oncogenes and chemical mutagens and may provide insight into the molecular genetic events which accompany the stepwise induct ion of prostatic neoplasia.