SEQUENTIAL OXIDATIVE DAMAGE, AND CHANGES IN IRON-BINDING AND IRON-OXIDIZING PLASMA ANTIOXIDANTS DURING CARDIOPULMONARY BYPASS-SURGERY

Citation
Jr. Pepper et al., SEQUENTIAL OXIDATIVE DAMAGE, AND CHANGES IN IRON-BINDING AND IRON-OXIDIZING PLASMA ANTIOXIDANTS DURING CARDIOPULMONARY BYPASS-SURGERY, Free radical research, 21(6), 1994, pp. 377-385
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biology
Journal title
ISSN journal
1071-5762
Volume
21
Issue
6
Year of publication
1994
Pages
377 - 385
Database
ISI
SICI code
1071-5762(1994)21:6<377:SODACI>2.0.ZU;2-6
Abstract
Cardiopulmonary bypass patients undergoing heart valve replacement sur gery appear to be under oxidative stress, when compared with normal he althy controls, by showing increased levels of protein and lipid damag e. During bypass surgery two further episodes of oxidative stress occu r. The first is seen when patients are placed on extracorporeal blood circulation and oxygenation which results in a rise in lipid peroxides and thiobarbituric acid-reactive substances. The second phase of oxid ative stress occurs during reperfusion of the myocardium following rem oval of the aortic cross clamp. Coincident with evidence of increased oxidative damage to lipids during these latter phases of oxidative str ess were decreases in plasma iron-binding and iron-oxidising antioxida nt activities.