Jr. Pepper et al., SEQUENTIAL OXIDATIVE DAMAGE, AND CHANGES IN IRON-BINDING AND IRON-OXIDIZING PLASMA ANTIOXIDANTS DURING CARDIOPULMONARY BYPASS-SURGERY, Free radical research, 21(6), 1994, pp. 377-385
Cardiopulmonary bypass patients undergoing heart valve replacement sur
gery appear to be under oxidative stress, when compared with normal he
althy controls, by showing increased levels of protein and lipid damag
e. During bypass surgery two further episodes of oxidative stress occu
r. The first is seen when patients are placed on extracorporeal blood
circulation and oxygenation which results in a rise in lipid peroxides
and thiobarbituric acid-reactive substances. The second phase of oxid
ative stress occurs during reperfusion of the myocardium following rem
oval of the aortic cross clamp. Coincident with evidence of increased
oxidative damage to lipids during these latter phases of oxidative str
ess were decreases in plasma iron-binding and iron-oxidising antioxida
nt activities.