BASAL SERUM GASTRIN-CONCENTRATIONS BEFORE AND AFTER ERADICATION OF HELICOBACTER-PYLORI INFECTION MEASURED BY SEQUENCE-SPECIFIC RADIOIMMUNOASSAYS

Citation
Em. Witteman et al., BASAL SERUM GASTRIN-CONCENTRATIONS BEFORE AND AFTER ERADICATION OF HELICOBACTER-PYLORI INFECTION MEASURED BY SEQUENCE-SPECIFIC RADIOIMMUNOASSAYS, Alimentary pharmacology & therapeutics, 8(5), 1994, pp. 515-519
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Pharmacy
ISSN journal
0269-2813
Volume
8
Issue
5
Year of publication
1994
Pages
515 - 519
Database
ISI
SICI code
0269-2813(1994)8:5<515:BSGBAA>2.0.ZU;2-8
Abstract
Background: Helicobacter pylori infection of the antral mucosa is resp onsible for an increase in basal and stimulated serum gastrin. In the present study we have investigated whether gastritis induced by H. pyl ori is responsible for abnormalities in the processing of gastrin in d yspeptic patients. Methods: Basal serum gastrin was measured by radioi mmunoassay before, 5 weeks, and 1 year after anti-H. pylori therapy in 73 H. pylori positive functional dyspeptic patients. Three region-spe cific antisera were used, specific for the biologically active carboxy -terminal part, the biologically inactive amino-terminal part of gastr in 1-17, and for the non-sulphated tyrosyl residue in gastrin 1-17. Re sults: Basal serum gastrin levels were markedly (P < 0.01) decreased 5 weeks and 1 year after successful eradication of H. pylori (n = 39) b ut not in the patients in whom treatment failed (n = 34). A decline of gastrin was observed for each of the three radioimmunoassays. Conclus ion: The decrease of serum gastrin levels in all three radioimmunoassa ys after a successful eradication of H. pylori does not point to major changes in the processing of gastrin. These results suggest that G-ce lls in the antral mucosa are not functionally affected by the inflamma tion.