A series of experiments was performed, which indicated that 7-OHDPAT i
s only active in rats that are still in the dynamic phase of the devel
opment of a high and stable level of alcohol preference and in a drug
discrimination test procedure, but not in rats with a matured preferen
ce for 3% alcohol. These data may point to a limited use of 7-OHDPAT i
n conditions of alcohol misuse and dependence.