The effects of acute intraperitoneal administration of ethanol (1-3 g/
kg body wt) on the extracellular concentrations of glutamate (GLU), ta
urine (TAU) and gamma-aminobutyric acid (GABA) in rat brain nucleus ac
cumbens were studied by the microdialysis technique coupled to HPLC-EC
detection. Levels GLU and GABA were not affected by ethanol, whereas
those TAU were increased by doses of the drug of 2-3 g/kg.