M. Viswanathan et al., EXPRESSION OF A NOVEL NON-ANGIOTENSIN-II [I-125] CGP-42112 BINDING-SITE IN HEALING WOUNDS OF THE RAT-BRAIN, Brain research, 658(1-2), 1994, pp. 265-270
We characterized a novel non-angiotensin II binding site that is recog
nized by the angiotensin II AT(2) receptor ligand [I-125]CGP 42112, in
healing brain wounds of adult rats. The binding, which was highest at
3 days after injury, appears to be localized to activated microglia s
urrounding the wound. The novel CGP 42112 binding site may have a role
in the function of microglia and in mechanisms of tissue repair in th
e brain.