EXPRESSION OF A NOVEL NON-ANGIOTENSIN-II [I-125] CGP-42112 BINDING-SITE IN HEALING WOUNDS OF THE RAT-BRAIN

Citation
M. Viswanathan et al., EXPRESSION OF A NOVEL NON-ANGIOTENSIN-II [I-125] CGP-42112 BINDING-SITE IN HEALING WOUNDS OF THE RAT-BRAIN, Brain research, 658(1-2), 1994, pp. 265-270
Citations number
28
Language
INGLESE
art.tipo
Note
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
0006-8993
Volume
658
Issue
1-2
Year of publication
1994
Pages
265 - 270
Database
ISI
SICI code
0006-8993(1994)658:1-2<265:EOANN[>2.0.ZU;2-J
Abstract
We characterized a novel non-angiotensin II binding site that is recog nized by the angiotensin II AT(2) receptor ligand [I-125]CGP 42112, in healing brain wounds of adult rats. The binding, which was highest at 3 days after injury, appears to be localized to activated microglia s urrounding the wound. The novel CGP 42112 binding site may have a role in the function of microglia and in mechanisms of tissue repair in th e brain.