INVOLVEMENT OF D2 DOPAMINE-RECEPTORS IN THE NUCLEUS-ACCUMBENS IN THE OPIATE WITHDRAWAL SYNDROME

Citation
Gc. Harris et G. Astonjones, INVOLVEMENT OF D2 DOPAMINE-RECEPTORS IN THE NUCLEUS-ACCUMBENS IN THE OPIATE WITHDRAWAL SYNDROME, Nature, 371(6493), 1994, pp. 155-157
Citations number
30
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Multidisciplinary Sciences
Journal title
NatureACNP
ISSN journal
0028-0836
Volume
371
Issue
6493
Year of publication
1994
Pages
155 - 157
Database
ISI
SICI code
0028-0836(1994)371:6493<155:IODDIT>2.0.ZU;2-X
Abstract
THE nucleus accumbens is prominently implicated in the reinforcing eff ects of abused drugs(1-4), and is an important site for mediating aver sive stimulus properties of opiate withdrawal(5). It is generally thou ght, however, that the role of the accumbens is negligible in the soma tic signs of opiate withdrawal(5-7). Contrary to this assumption, we n ow report that D2 dopaminergic receptor activity in the accumbens area potently regulates somatic symptoms of opiate withdrawal. We find tha t activation of D2 receptors within the accumbens prevents somatic sig ns of naloxone-induced opiate withdrawal and, conversely, that blockad e of accumbal D2 receptors in opiate-dependent animals elicits somatic withdrawal symptoms. These data indicate that dopamine in the accumbe ns not only is important in the rewarding effects of abused drugs, but also (via D2 receptors) plays a pivotal role in opiate withdrawal.