CIRCADIAN RHYTHMIC VARIATIONS IN SERUM CONCENTRATIONS OF CLINICALLY IMPORTANT LIPIDS

Citation
A. Riveracoll et al., CIRCADIAN RHYTHMIC VARIATIONS IN SERUM CONCENTRATIONS OF CLINICALLY IMPORTANT LIPIDS, Clinical chemistry, 40(8), 1994, pp. 1549-1553
Citations number
33
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry Medicinal
Journal title
ISSN journal
0009-9147
Volume
40
Issue
8
Year of publication
1994
Pages
1549 - 1553
Database
ISI
SICI code
0009-9147(1994)40:8<1549:CRVISC>2.0.ZU;2-8
Abstract
Twenty-five apparently healthy adults (13 men and 12 women), mean age 29.5 years (SD 3.6 years), served as subjects in a 24-h study conducte d in Barcelona (Spain) in spring of 1990. Six blood samples were colle cted from each subject at 4-h intervals over a 24-h period, beginning at 1000. The oral temperature was measured at 2-h intervals to facilit ate an independent biological time reference. The serum concentrations of apolipoprotein (ape) A-I, apo B, cholesterol, high- and low-densit y lipoprotein cholesterol, and triglyceride were measured. The circadi an rhythms of these quantities were studied with use of a periodic fun ction resulting from the sum of two cosine functions of 24 and 12 h. F or serum concentrations of apo A-I and apo B, only the 24- or 12-h com ponents, respectively, were significant. However, the other quantities studied were significantly affected by both rhythmic components. The maximum daily rhythmic variation ranged from 5% (with respect to the d aily mean) for apo A-I to 63% for triglyceride concentration. In all c ases except triglyceride, the daily maximum values were measured in th e afternoon samples, near the time of maximum oral temperature.