A NOVEL MECHANISM OF IN-VIVO RAS GENE ACTIVATION INVOLVING TANDEM DUPLICATION OF CODING SEQUENCES

Citation
Js. Wiest et al., A NOVEL MECHANISM OF IN-VIVO RAS GENE ACTIVATION INVOLVING TANDEM DUPLICATION OF CODING SEQUENCES, Oncogene, 9(9), 1994, pp. 2449-2454
Citations number
39
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Genetics & Heredity",Oncology
Journal title
ISSN journal
0950-9232
Volume
9
Issue
9
Year of publication
1994
Pages
2449 - 2454
Database
ISI
SICI code
0950-9232(1994)9:9<2449:ANMOIR>2.0.ZU;2-R
Abstract
A series of weakly transforming c-K-ras genes have been detected in sp ontaneously occurring and chemically induced mouse adenomas. DNA seque nce analysis of these weakly transforming ras oncogenes showed that ac tivation occurred by a novel mechanism involving duplication of nine o r ten codon segments flanking codon 61 in exon 2. The codon repetition s in exon 2 are directly preceded by a number of potentially recombino genic DNA sequences which may have been involved in the genesis of the codon repetitions through mechanisms involving recombination or DNA s lippage. Duplication of DNA sequences such as those observed in the mo use c-K-ras gene may represent a new mechanism for both tumor suppress or gene inactivation and proto-oncogene activation.