-TETRAHYDROISOQUINOL-3-YLCARBONYL)-L-PHENYLALANINE METHYL-ESTER, Z-L-TIC-L-PHE-OME

Citation
L. Vitagliano et al., -TETRAHYDROISOQUINOL-3-YLCARBONYL)-L-PHENYLALANINE METHYL-ESTER, Z-L-TIC-L-PHE-OME, Acta crystallographica. Section C, Crystal structure communications, 50, 1994, pp. 1135-1138
Citations number
11
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Crystallography
ISSN journal
0108-2701
Volume
50
Year of publication
1994
Part
7
Pages
1135 - 1138
Database
ISI
SICI code
0108-2701(1994)50:<1135:-MZ>2.0.ZU;2-J
Abstract
The title compound, C28H28N2O5, is a terminally blocked dipeptide, con formationally constrained by the presence of a 1,2,3,4-tetrahydroisoqu inoline residue (Tic). The conformation of the peptide linkage is tran s [omega1 = -177.0 (3)-degrees] and the main chain conformation is det ermined by the parameters phi1 = - 86.7 (4), psi1 = 171.5 (3), phi2 = - 77.2 (4), psi(tau) = 160.1 (3)-degrees. The side chain of Tic is in a g+ conformation [chi1(1) = 56.0 (4)-degrees], whereas the phenylalan ine side chain is in a g- conformation [chi2(1) = -68.8 (5)-degrees]. In the crystal the molecules are held together by an intermolecular hy drogen bond and van der Waals forces between hydrophobic phenyl groups .