RISK OF ARTERIAL THROMBOSIS IN PATIENTS WITH ANTICARDIOLIPIN ANTIBODIES AND LUPUS ANTICOAGULANT

Citation
J. Nojima et al., RISK OF ARTERIAL THROMBOSIS IN PATIENTS WITH ANTICARDIOLIPIN ANTIBODIES AND LUPUS ANTICOAGULANT, British Journal of Haematology, 96(3), 1997, pp. 447-450
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology
ISSN journal
0007-1048
Volume
96
Issue
3
Year of publication
1997
Pages
447 - 450
Database
ISI
SICI code
0007-1048(1997)96:3<447:ROATIP>2.0.ZU;2-M
Abstract
The relationship between arterial or venous thrombosis and the levels of anticardiolipin antibodies (aCL) and/or existence of lupus anticoag ulant (LA) was studied. The 141 patients with systemic lupus erythemat osus (SLE) were divided into four groups: aCL single positive (25 case s), LA single positive (11 cases), aCL and LA double positive (25 case s), aCL and LA double negative (80 cases). The prevalence of thrombosi s was higher in aCL and LA double positive patients (21/25 cases, 84.0 %, P < 0.01) than that in aCL single positive patients (4/25 cases, 16 .0%), LA single positive patients (1/11 cases, 9.1%) and double negati ve patients (3/80 cases, 3.8%), Furthermore, in these double positive patients, all patients (10/10 cases) with a high positive level of aCL (> 10 units/ml) had arterial thrombosis, whereas only 2/15 patients ( 13.3%) with a low positive level of aCL (3-10 units/ml) were affected, Venous thrombosis was frequently found in the low positive group (9/1 5 cases, 60.0%). On the contrary, none of 105 LA negative patients had arterial thrombosis and only seven (6.7%) had venous thrombosis. Thes e findings indicate that a high aCL activity combined with a LA positi ve result might be a risk factor for arterial thrombosis.