SYNTHESIS OF SOME NEW FLUORINE-CONTAINING OXAZOLES, OXADIAZOLES, THIADIAZOLES AND TRIAZINES

Citation
Vn. Pathak et al., SYNTHESIS OF SOME NEW FLUORINE-CONTAINING OXAZOLES, OXADIAZOLES, THIADIAZOLES AND TRIAZINES, Journal of the Indian Chemical Society, 70(6), 1993, pp. 539-542
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry
ISSN journal
0019-4522
Volume
70
Issue
6
Year of publication
1993
Pages
539 - 542
Database
ISI
SICI code
0019-4522(1993)70:6<539:SOSNFO>2.0.ZU;2-2
Abstract
Treatment of fluorine containing phenacyl bromides with urea or substi tuted arylureas afforded the corresponding 2-(amino/N-arylamino)-4-(fl uoroaryl)oxazoles, and with ammonium acetate in glacial acetic acid yi elded 2-methyl-4-(fluoroaryl)oxazoles. Fluorinated arylglyoxals on ref luxing with semicarbazide or thiosemicarbazide afforded arylglyoxalsem icarbazones/or thiosemicarbazones, cyclisation of these with potassium carbonate in aqueous ethanol afforded 1,2,4-triazines, while with sod ium acetate and sodium bromide in acetic acid yielded 1,3,4-oxadiazole s/or -thiadiazoles. The structures of the compounds have been establis hed by analytical and ir, H-1 nmr and mass spectral data.