AMYLOID-BETA PROTEIN AND TRANSTHYRETIN, SEQUESTRATING PROTEIN COLOCALIZE IN NORMAL HUMAN KIDNEY

Citation
K. Tsuzuki et al., AMYLOID-BETA PROTEIN AND TRANSTHYRETIN, SEQUESTRATING PROTEIN COLOCALIZE IN NORMAL HUMAN KIDNEY, Neuroscience letters, 222(3), 1997, pp. 163-166
Citations number
22
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
0304-3940
Volume
222
Issue
3
Year of publication
1997
Pages
163 - 166
Database
ISI
SICI code
0304-3940(1997)222:3<163:APATSP>2.0.ZU;2-U
Abstract
The localization of amyloid beta protein (A beta), A beta 40, A beta 4 2, and transthyretin (TTR) was investigated immunohistochemically in t he autopsied human kidney, using polyclonal antibodies against TTR, A beta and C-terminal end-specific antibodies against A beta 40 and 42. Immunoreactivities of A beta and A beta 40 were found both in the prox imal and distal tubular epithelial cells. But the immunolocalization o f A beta 40 was observed predominantly in the distal tubules whereas t hat of A beta 42 was predominantly recognized in the proximal tubules. TTR, sequestrating protein for A beta, was present in the proximal tu bules. The mechanism by which A beta does not form amyloid in Alzheime r's disease outside the brain remains unknown. The tubular epithelial cells in the kidney may provide a useful system to shed light on this issue. (C) 1997 Elsevier Science Ireland Ltd.