AMMONIA HYPERSENSITIVITY OF SLUGGER MUTANTS OF D-DISCOIDEUM

Citation
K. Gee et al., AMMONIA HYPERSENSITIVITY OF SLUGGER MUTANTS OF D-DISCOIDEUM, Journal of Cell Science, 107, 1994, pp. 701-708
Citations number
28
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cytology & Histology
Journal title
ISSN journal
0021-9533
Volume
107
Year of publication
1994
Part
2
Pages
701 - 708
Database
ISI
SICI code
0021-9533(1994)107:<701:AHOSMO>2.0.ZU;2-3
Abstract
The weak base ammonia inhibits aggregation and culmination of wild-typ e amoebae of Dictyostelium discoideum. Here we have examined its effec t on a series of 'slugger' mutants previously assigned to 10 complemen tation groups, and so-called because they remain as slugs for extended periods. We show that the mutants accumulate normal levels of ammonia and hence may be abnormally susceptible to the ammonia they produce. In agreement with this we find that representatives of the slugger com plementation groups are hypersensitive to ammonia inhibition at three dearly recognisable morphological stages of development: aggregation, tip formation and culmination. This finding suggests that a common amm onia-sensitive process underlies each of these developmental events.