EXTREMELY HIGH HDL LEVELS IN A PATIENT WITH MULTIPLE SYMMETRICAL LIPOMATOSIS

Citation
L. Deiana et al., EXTREMELY HIGH HDL LEVELS IN A PATIENT WITH MULTIPLE SYMMETRICAL LIPOMATOSIS, Clinica chimica acta, 223(1-2), 1993, pp. 143-147
Citations number
9
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry Medicinal
Journal title
ISSN journal
0009-8981
Volume
223
Issue
1-2
Year of publication
1993
Pages
143 - 147
Database
ISI
SICI code
0009-8981(1993)223:1-2<143:EHHLIA>2.0.ZU;2-9
Abstract
An extreme form of hyperalphalipoproteinemia was studied in a patient affected by multiple symmetric lipomatosis (MSL); four relatives and t hree MSL controls were also evaluated. Plasma lipids and apolipoprotei ns were measured and overall lipoprotein profile was assessed by densi ty gradient ultracentrifugation. The patient showed a plasma HDL-chole sterol of 138 mg/dl and an apo A-I of 218 mg/dl; moreover significantl y high HDL levels were found in two unaffected relatives. The hypobeta lipoproteinemia trait was also found both in the patient and in one of his daughters. We suggest that some pre-existing conditions may enhan ce lipoprotein metabolism alterations in this lipid storage disease.