LIPOPROTEIN COMPOSITION IN THE INSULIN-DEFICIENT NON-ACIDOTIC PHASE OF TYPE-I DIABETIC-PATIENTS AND EARLY EVOLUTION AFTER THE START OF INSULIN THERAPY

Citation
Jl. Reverter et al., LIPOPROTEIN COMPOSITION IN THE INSULIN-DEFICIENT NON-ACIDOTIC PHASE OF TYPE-I DIABETIC-PATIENTS AND EARLY EVOLUTION AFTER THE START OF INSULIN THERAPY, Clinica chimica acta, 223(1-2), 1993, pp. 113-120
Citations number
30
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry Medicinal
Journal title
ISSN journal
0009-8981
Volume
223
Issue
1-2
Year of publication
1993
Pages
113 - 120
Database
ISI
SICI code
0009-8981(1993)223:1-2<113:LCITIN>2.0.ZU;2-#
Abstract
Lipoproteins, including intermediate density lipoproteins and lipoprot ein(a), and apolipoproteins A-I, B, C-II, C-III and E, were studied in 13 newly-diagnosed type I diabetic patients with severe insulinopenia without dehydration or acidosis. At baseline, the main finding was a significant increase in serum triglycerides due to raised triglyceride concentrations in all lipoproteins, particularly triglyceride-rich li poproteins. Cholesterol concentrations were slightly increased in lipo proteins and led to a significant increase in serum cholesterol. Two d ays after the start of insulin therapy, lipoprotein profiles had norma lized except for the LDL triglyceride contents, which remained signifi cantly increased on the fifth day of treatment. No significant modific ations were observed in lipoprotein(a), apolipoproteins A-I and E conc entrations throughout the study. However, serum apolipoproteins B, C-I I and C-III were increased at baseline and fell to normal levels 2 day s after the start of insulin therapy. On the other hand, apolipoprotei n C-II/C-III ratios in high and very low density lipoprotein, showed n o significant differences at baseline compared with controls, suggesti ng that an apolipoprotein C-II deficiency or apolipoproteins Cs imbala nce can be ruled out. In conclusion, significant lipoprotein abnormali ties were observed in the insulin-deficient state of type I diabetes m ellitus; insulin therapy normalizes the lipoprotein profile in two day s, except for low density lipoprotein triglyceride contents which rema in increased at the fifth day.