LACTATE-DEHYDROGENASE ISOENZYME PATTERNS IN BLOOD-CELLS FROM HISTIOCYTOSIS X CHILDREN

Citation
E. Perlino et al., LACTATE-DEHYDROGENASE ISOENZYME PATTERNS IN BLOOD-CELLS FROM HISTIOCYTOSIS X CHILDREN, Clinica chimica acta, 223(1-2), 1993, pp. 83-91
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry Medicinal
Journal title
ISSN journal
0009-8981
Volume
223
Issue
1-2
Year of publication
1993
Pages
83 - 91
Database
ISI
SICI code
0009-8981(1993)223:1-2<83:LIPIBF>2.0.ZU;2-1
Abstract
To find a clinical assay for histiocytosis X (HX) diagnosis, measureme nts were made of both activity and isoenzyme distribution of lactate d ehydrogenase (LDH; EC 1.1.1.27) from the blood cells of 6 acute phase and 9 remission patients. A significant increase in the LDH activity m easured in the monocytes and lymphocytes isolated from the blood of th e acute phase patients was found. The increased activity was due to an enhancement of the normal pattern of LDH isoenzymes in these cells an d not to a change in isoenzyme distribution. No increase was found in monocyte LDH isoenzymes from the patients in remission.