THE RELATIONSHIP BETWEEN SERUM LEVELS OF LIPOPROTEIN(A) AND PROTEINS ASSOCIATED WITH THE ACUTE-PHASE RESPONSE

Citation
Tb. Ledue et al., THE RELATIONSHIP BETWEEN SERUM LEVELS OF LIPOPROTEIN(A) AND PROTEINS ASSOCIATED WITH THE ACUTE-PHASE RESPONSE, Clinica chimica acta, 223(1-2), 1993, pp. 73-82
Citations number
34
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry Medicinal
Journal title
ISSN journal
0009-8981
Volume
223
Issue
1-2
Year of publication
1993
Pages
73 - 82
Database
ISI
SICI code
0009-8981(1993)223:1-2<73:TRBSLO>2.0.ZU;2-R
Abstract
The association of serum lipoprotein(a) (Lp(a)) with inflammation was investigated in a primarily rheumatologic study group (n = 570; 202 ma les and 368 females) by Studying the relationship between serum levels of Lp(a) and a panel of acute phase proteins (C-reactive protein (CRP ), alpha(1)-antitrypsin (AAT), alpha(1)-acid glycoprotein (AGP), hapto globin (HPT), complement components 3 and 4 (C3, C4), prealbumin (PAL) , albumin (ALB) and transferrin (TRF)). Lp(a) data were adjusted for a ge and sex, but not clinical condition as no significant differences i n Lp(a) levels were observed, using analysis of variance, among the 15 diagnostic categories in the study group. Univariate analyses reveale d significant positive associations between Lp(a) levels and levels of C4, AGP, C3 and HPT. Multivariate analysis revealed that C4 and AGP ( in descending order of significance) were significant independent pred ictors of Lp(a) concentration, together accounting for 2.9% of the var iability in Lp(a) concentration in the present study group. The data i ndicate that confounding effects of an acute phase response should be considered in epidemiologic studies, if a high prevalence of inflammat ion is suspected.